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Regeneration is a mechanism of response to depopulation of a cell cohort due to radiation damage, and depends on the types of tissue and their proliferating capacity. Reoxygenation discussed earlier is an effect that makes the hypoxic cells more radiosensitive in the presence of oxygen in fractionated radiotherapy. Sublethal damage repair depends very much on the dose rate and in which stage of the cell cycles the cells are. For example, the testis of male rats is most radiosensitive, whereas the small intestine seems to be less affected by radiation.

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